Preliminary Technical Program (mSBW 5.0)

Saturday, May 5th

7:00 AM 12:00 PM REGISTRATION
7:30 AM 8:15 AM BREAKFAST
8:15 AM 8:30 AM WELCOMING REMARKS George Daley, Dean of Harvard Medical School
8:30 AM 9:15 AM PLENARY SPEAKER: Remote Control CARs to Prevent and Reverse T Cell Exhaustion Crystal Mackall, Stanford University
9:15 AM 10:45 AM SESSION 1: SYNTHETIC IMMUNOLOGY
9:15 AM 9:45 AM INVITED SPEAKER: TBA Alexander Marson, University of California, San Francisco
9:45 AM 10:15 AM INVITED SPEAKER: Hacking Immune Cells to Expand Their Therapeutic Potential Kole Roybal, University of California, San Francisco
10:15 AM 10:30 AM Covert T Cells: Engineering T Cells to Interrogate Intracellular Antigens Patrick Ho, University of California, Los Angeles
10:30 AM 10:45 AM Impact of microRNAs on Cellular Burden Federica Cella, University of Genoa, NBT Department, Italian Institute of Technology
10:45 AM 11:15 AM BREAK 
11:15 AM 12:45 PM SESSION 2: GENES, CIRCUITS, AND GENOMES
11:15 AM 11:45 AM INVITED SPEAKER:  Enforcing Homogeneity in a Complex and Heterogeneous System: “It Always Seems Impossible until It Is Done." (Nelson Mandela) Nicole Borth, University of Natural Resources and Life Sciences, Vienna
11:45 AM 12:15 PM INVITED SPEAKER: Base Editing: Chemistry on a Target Nucleotide in the Genome of Living Cells David Liu, The Broad Institute of Harvard and MIT
12:15 PM 12:30 PM Programmable Protein Circuits in Living Cells Xiaojing Gao, California Institute of Technology
12:30 PM 12:45 PM Slick Software, Slow Hardware: Balancing Biophysical Tradeoffs to Drive Cellular Reprogramming Kate E. Galloway, University of Southern California
12:45 PM 2:00 PM LUNCH
2:00 PM 3:30 PM SESSION 3: THE FUTURE OF SYNTHETIC BIOLOGY FUNDING AND INVESTMENT
2:00 PM 2:05 PM Introduction, Moderator: Nevin Summers, Massachusetts Institute of Technology Synthetic Biology Center
2:05 PM 2:55 PM Panelists Short Talks
2:55 PM 3:10 PM Panel Discussion: The Future of Synthetic Biology Funding and Investment, Devaki Bhaya, National Science Foundation, Aubrey D.N.J. de Grey, SENS Research Foundation, Peter T. Lomedico, JDRF T1D Fund, Annie Mitsak, Omega Fund Management, Dylan Morris, Charles River Ventures, David Rampulla, National Institute for Biomedical Imaging and Bioengineering
3:10 PM 3:30 PM Questions from the Audience
3:30 PM 4:00 PM BREAK
4:00 PM 5:30 PM SESSION 4: VIRAL VECTORS AND GENE THERAPY
4:00 PM 4:30 AM INVITED SPEAKER: TBA Clodagh O'Shea, Salk Institute for Biological Studies
4:30 PM 5:00 PM INVITED SPEAKER: Directed Evolution of New Viruses for Therapeutic Gene Delivery David Schaffer, University of California, Berkeley
5:00 PM 5:15 PM Synthesis at the Interface of Virology and Mammalian Genetic Code Expansion Abhishek Chatterjee, Boston College
5:15 PM 5:30 PM
Programmable Synthetic Gene Circuit As a Potential Therapeutic Intervention for Liver Cancer Zhen Xie Tsinghua, University, Beijing, China 
5:30 PM 6:30 PM Reception and Poster Session

Sunday, May 6th

7:30 AM 12:00 PM REGISTRATION
8:00 AM 8:30 AM BREAKFAST
8:30 AM 9:15 AM PLENARY SPEAKER: Identifying and Engineering Memory-Holding Neurons and Their Circuits Susumu Tonegawa, Massachusetts Institute of Technology
9:15 AM 10:30 AM SESSION 5: SYNTHETIC BIOLOGY OF MULTICELLULAR SYSTEMS
9:15 AM 9:45 AM INVITED SPEAKER: A Synthetic Planar Cell Polarity System Reveals Localized Feedback on Fat4-Ds1 Complexes David Sprinzak, Tel-Aviv University
9:45 AM 10:15 AM INVITED SPEAKER: Motifs in Morphogenesis Lakshminarayanan Mahadevan, Harvard University
10:15 AM 10:30 AM Programming Self-Organizing Multicellular Shapes Jesse Tordoff, Massachusetts Institute of Technology
10:30 AM 10:45 AM BREAK 
10:45 AM 12:15 PM SESSION 6: HOST-MICROBE INTERACTIONS
10:45 AM 11:15 AM INVITED SPEAKER: Speeding up Mammalian Synthetic Biology James J. Collins, Massachusetts Institute of Technology
11:15 AM 11:45 AM INVITED SPEAKER: Synthetic Exploration of the Host Microbe Interactions in the Mammalian Gut Pamela Silver, Harvard Medical School 
11:45 AM 12:15 PM INVITED SPEAKER: Building Communities from the Bottom Up Jeff Gore, Massachusetts Institute of Technology
12:15 PM 12:30 PM BREAK
12:30 PM 1:00 PM Closing Session with George Church, Harvard University